Table 2.
Noradrenaline metabolite overflow in healthy subjects (DHPG and MHPG)
| Plasma concentration |
Blood flow (ml min−1) | MHPG and DHPG overflows for L and R jugular (ng min−1) | Total metabolite overflow for pooled R jugular (ng min−1) | ||
|---|---|---|---|---|---|
| ART (pg ml−1) | JV (pg ml−1) | ||||
| MHPG | 2783.1 ± 86.03 | 3119.4 ± 103.5 | 421.2 ± 26.1 | 114.9 ± 28.6 | 180 ± 29.8*† |
| RJV | (n= 37)‡ | (n= 37)‡ | (n= 47)‡ | (n= 37)‡ | |
| DHPG | 947.2 ± 27.4 | 1065.6 ± 37.9 | 421.2 ± 26.1 | 47.3 ± 10.4 | (Right side, n= 36)‡ |
| RJV | (n= 46)‡ | (n= 46)‡ | (n= 47)‡ | (n= 45)‡ | |
| MHPG | 2935.4 ± 186.3 | 3362.8 ± 252.2 | 384.8 ± 27.2 | 166.6 ± 43.9 | 199.2 ± 46.9*† |
| LJV | (n= 18)‡ | (n= 18)‡ | (n= 25)‡ | (n= 18)‡ | |
| DHPG | 959.2 ± 29.7 | 1080.35 ± 41.0 | 384.8 ± 27.2 | 38.3 ± 10.2 | (Left side, n= 18)‡ |
| LJV | (n= 26)‡ | (n= 26)‡ | (n= 25)‡ | (n= 25)‡ | |
*
The mean noradrenaline metabolite overflow for both left and right JV samples was 186.4 ± 25 ng min−1.
†
The total metabolite overflow for the brain is therefore approximately double the mean unilateral measurement, i.e. approximately 373 ng min−1.
‡
We were not able to obtain DHPG or MHPG assays and blood flows on all healthy subjects. Hence the number obtained per unilateral sample is expressed as (n=x).