Table 3.

Multivariable Cox regression model with myeloperoxidase (MPO) expressed in quartiles in subjects without a history of myocardial infarction (MI)

	HR (95% CI)	p value	HR* (95% CI)	p Value
MPO quartiles (pmol/L)
<170	1.0 (reference)		1.0 (reference)
170–261	1.42 (1.06–1.91)	0.02	1.42 (1.05–1.90)	0.02
262–432	0.96 (0.70–1.33)	0.81	0.91 (0.66–1.25)	0.55
>432	1.62 (1.20–2.17)	<0.01	1.46 (1.08–1.97)	0.02
Age (yrs)	1.09 (1.07–1.11)	<0.01	1.08 (1.06–1.10)	<0.01
Men	1.31 (1.06–1.62)	0.01	1.33 (1.07–1.64)	0.01
Systolic blood pressure (mm Hg)†	1.29 (1.17–1.42)	<0.01	1.28 (1.16–1.41)	<0.01
Smoker (current)	1.42 (1.01–2.00)	0.05	1.35 (0.96–1.90)	0.09
LDL cholesterol (mg/dl)†	0.90 (0.81–1.00)	0.06	0.92 (0.82–1.02)	0.11
Diabetes mellitus	1.96 (1.51–2.53)	<0.01	1.82 (1.40–2.36)	<0.01
Subclinical cardiovascular diseases	1.89 (1.44–2.48)	<0.01	1.82 (1.39–2.39)	<0.01
C-Reactive protein†	—	—	1.12(1.04–1.22)	0.04
Cystatin C†	—	—	1.26(1.19–1.34)	<0.01

^*When CRP and cystatin C were added to the multivariate model.

^†Per standard deviation increments (systolic blood presure = 21 mmHg, LDL cholesterol = 33 mg/dL, C-reactive protein = 9.4 mg/L, cystatin C = 0.28 mg/L).