Table 4.

Marker levels for the controls and cases by risk status. The marker values have been log transformed and standardized to mean=0 and standard deviation=1 in the average risk controls.

	Average Rsik		High Risk		p-value*
	n	Mean (SE)	n	Mean (SE)
HEALTHY CONTROLS	150		294
CA125		0 (1.0)		−0.8 (0.8)	<0.001
Mesothelin		0 (1.0)		0.1 (1.0)	0.63
HE4		0 (1.0)		−0.2 (1.0)	0.10
BENIGN CONTROLS	110		14
CA125		0.7 (1.4)		0.5 (1.1)	0.67
Mesothelin		0.02 (1.2)		0.1 (1.1)	0.79
HE4		0.43 (1.3)		0.3 (1.3)	0.95
CASES	102		41
CA125		4.2 (2.6)		3.6 (2.6)	0.17
Mesothelin		2.6 (2.8)		2.2 (2.8)	0.38
HE4		5.2 (3.9)		5.5 (3.6)	0.63
CASES (by histology)
Clear Cell	8		2
CA125		1.8 (2.0)		0.6 (0.1)	0.15
Mesothelin		0.3 (1.1)		−1.0 (0.5)	0.09
HE4		0.7 (1.3)		2.1 (0.8)	0.17
Endometrioed	10		4
CA125		4.7 (3.1)		3.5 (4.2)	0.61
Mesothelin		1.2 (2.2)		0.9 (3.2)	0.85
HE4		4.9 (3.4)		5.7 (4.8)	0.77
Mucinous	6		2
CA125		3.0 (1.9)		3.4 (1.5)	0.80
Mesothelin		−0.2 (0.6)		1.8 (0.2)	<0.001
HE4		1.6 (1.4)		6.7 (0.8)	0.006
Serous	66		24
CA125		4.8 (2.4)		4.4 (2.1)	0.50
Mesothelin		3.7 (2.6)		2.8 (2.6)	0.16
HE4		6.4 (3.8)		6.3 (3.5)	0.95
Other	12		9
CA125		3.1 (2.9)		2.1 (2.8)	0.42
Mesothelin		1.0 (2.5)		1.9 (3.3)	0.50
HE4		3.8 (3.5)		3.9 (3.7)	0.93
CASES (by stage)
Stage 1	29		6
CA125		2.5 (2.6)		2.8 (2.5)	0.85
Mesothelin		0.4 (1.4)		0.2 (1.7)	0.82
HE4		1.7 (2.0)		3.9 (3.2)	0.15
Stage 2	7		3
CA125		3.4 (2.3)		2.8 (2.4)	0.73
Mesothelin		1.0 (1.3)		2.3 (3.7)	0.62
HE4		5.3 (3.0)		6.2 (2.1)	0.63
Stage 3	53		22
CA125		5.3 (2.1)		4.4 (2.2)	0.12
Mesothelin		3.8 (2.7)		3.0 (2.9)	0.26
HE4		7.1 (3.5)		6.8 (3.1)	0.72
Stage 4	10		4
CA125		4.6 (2.8)		5.8 (1.6)	0.38
Mesothelin		3.4 (3.0)		3.2 (2.6)	0.88
HE4		4.5 (3.3)		7.9 (2.1)	0.05

^*p-values were obtained from the Student's t-test.