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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1365–1372. doi: 10.1158/1055-9965.EPI-08-1034

Table 5.

Diagnostic accuracy of the biomarkers for average and high risk women.

Cases vs. Healthy Controls Cases vs. Benign Controls
AUC Sensitivity at
95% Specificity		 Sensitivity at
95% Specificity		 AUC Sensitivity at
95% Specificity		 Sensitivity at
98% Specificity
 CA125
   Average Risk 0.939 79.41 78.43 0.880 58.82 49.02
   High Risk 0.939 82.93 78.05 0.835 63.41 60.98
   AUC differences p-value* 0.98 0.45
 Mesothelin
   Average Risk 0.793 53.92 44.12 0.789 43.14 37.25
   High Risk 0.734 39.02 31.71 0.727 34.15 29.27
   AUC differences p-value* 0.36 0.42
 HE4
   Average Risk 0.928 80.39 68.63 0.883 61.76 57.84
   High Risk 0.931 87.80 82.93 0.902 75.61 70.73
   AUC differences p-value* 0.94 0.69
*

The AUC differences between the average risk and high risk women were compared for each biomarker using the non-parametric methods developed by DeLong29.