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. 2009 Jul 2;132(8):2219–2230. doi: 10.1093/brain/awp162

Figure 3.

Figure 3

Effect of ageing on DBP's transcription and protein levels in the cortex. tPA promoters analysis for the transcription factor DBP (albumin D-site binding protein) sequence in the different species analysed (A). Q-RT–PCR analysis for DBP in the perfused cortex (B) or hippocampus (C) as a function of age (n = 4). (D) The positive correlation between DBP and tPA mRNA cortical levels during ageing (blue squares: young animals; red squares: old animals). Immunostaining for tPA and DBP (E) in the perfused hippocampus with positive staining in mossy fibres and neuronal bodies, respectively. *Significantly different from 3-month-old mice, P < 0.05.