Table 3.
Case-control analysis in German Caucasians
| (a) All individuals without controlling for LD with HLA-DRB1 | |
| Minor allele | 250A |
| Allele frequency in cases/controls | 22%/33% |
| Total alleles of RA cases/controls | 178/368 |
| OR (95% CI) | 0.60 (0.4–0.9) |
| OR P value | 0.016 |
| (b) Subgroup without HLA-DRB1 risk alleles | |
| Frequency in cases/controls | 14%/34% |
| Total alleles of RA cases/controls | 50/216 |
| OR (95% CI) | 0.31 (0.1–0.7) |
| OR P value | 0.005 |
| (c) All individuals, controlling for LD with HLA-DRB1 by logistic regression | |
| OR (95% CI) | 0.6 (0.37–0.96) |
| P value | 0.032 |
| LRTa P value | 0.022 |
aLikelihood ratio test evaluating model including HLA-DRB1 alleles S2 and S3P and MICA-250 versus S2 and S3P only. For the HLA-DRB1 locus, allele L was used as reference. CI, confidence interval; LD, linkage disequilibrium; OR, odds ratio; RA, rheumatoid arthritis.