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. 2009 Jul 29;4(7):e6414. doi: 10.1371/journal.pone.0006414

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Mycobacterium bovis-infected cattle (n = 5) received 400 µg rESAT-6:CFP-10 intradermally and reactions were characterized after 6 days. Injection sites were collected at necropsy, fixed in formalin, and stained with hematoxylin and eosin. Injection sites consisted of predominately mononuclear cell infiltrates with intermittent, yet consistently detected, multi-nucleated giant cells (arrows). Prior studies have demonstrated that the inflammatory response to rESAT-6 is specific to M. bovis infection [48]. Also, intradermal injection of a BCG-vaccinated calf with 400 µg rESAT-6:CFP-10 did not elicit a DTH response and multi-nucleated giant cells were not detected within the injection site biopsy from this negative control animal.