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. 2009 Jun 9;100(12):1879–1888. doi: 10.1038/sj.bjc.6605034

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Copyright © 2009 Cancer Research UK

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GSI1 downregulates γ-secretase activity and the Notch pathway. (A) Relative γ-secretase activity in MCF-7 cells were treated with GSI1 for 24 h. (B) Western blot analysis of NICD in MCF-7 cells were treated with GSI1 for 24 h. (C) MCF-7 cells were transfected with a CBF1-luciferase reporter and the next day treated with GSI1 for 24 h. Values represent relative luciferase activity with respect to the mock-transfected and vehicle-treated cells. Bars indicate the average γ-secretase (A) or luciferase activity (C) ±s.d. of three independent experiments (^* indicates P<0.05).