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| Toxicity | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|
| Hypertension | 6 | 6 | 4 | 0 |
| Proteinuria | 0 | 1 | 1 | 0 |
| Haemorrhage | 3 | 4 | 3 | 0 |
| Thrombosis | 0 | 2 | 3 | 0 |
| Headache | 3 | 1 | 1 | 0 |
| Myocardial infarct | 0 | 0 | 0 | 1 |
One patient had grade 5 haemorrhage.
