Table 2.

Selected Adverse Events Leading to Discontinuation of a Study Drug.

Adverse Event	Telmisartan (N = 10,146)	Placebo (N = 10,186)	P Value
	no. (%)
Total	1450 (14.3)	1127 (11.1)	<0.001
Hypotensive symptoms	393 (3.9)	186 (1.8)	<0.001
Syncope	21 (0.2)	6 (0.1)	0.004
Uncontrolled hypertension	13 (0.1)	17 (0.2)	0.47
Headache	231 (2.3)	203 (2.0)	0.16
Diarrhea	69 (0.7)	45 (0.4)	0.02
Nausea	104 (1.0)	72 (0.7)	0.01
Vomiting	74 (0.7)	61 (0.6)	0.25
Angioedema	23 (0.2)	31 (0.3)	0.28
Renal impairment	28 (0.3)	18 (0.2)	0.14
Hyperkalemia	14 (0.1)	6 (0.1)	0.07
Atrial fibrillation	81 (0.8)	50 (0.5)	0.006