Table 1.
| ||||
---|---|---|---|---|
Entry | TfOH (mole%) |
Yieldb(%) |
||
a | b | c | ||
1 | 3 | 85 | 0 | 0 |
2 | 5 | 98 | 0 | 0 |
3 | 50 | 40 | 60 | 0 |
4 | 100 | 5 | 95 | 0 |
5 | 200 | 0 | 30 | 70 |
6 | 300 | 0 | 15 | 85 |
7 | 325 | 0 | 11 | 89 |
8 | 350 | 0 | 8 | 92 |
Reaction conditions: sulfonamide (0.636 mmol), 2,5-dimethoxytetrahydrofuran (5 eqv.), RT, 2h.
Based on sulfonamide, determined by GCMS.