Table 4.
| ||||
---|---|---|---|---|
Entry | Ar | Time (h) |
Selectivityb (%) |
Yieldc (%) |
1 | C6H5 | 2 | 92 | 79 |
2 | p-CH3C6H4 | 2 | 91 | 81 |
3 | p-OCH3C6H4 | 2 | 88 | 75 |
4 | p-BrC6H4 | 2 | 85 | 77 |
5 | o-CH3C6H4 | 2 | 91 | 82 |
6 | p-ClC6H4 | 2 | 93 | 86 |
7 | p-NO2C6H4 | 2 | 85 | 75 |
8 | Naphth-2-yl | 2 | 91 | 82 |
Reaction conditions: sulfonamide (0.636 mmol), 2,5-dimethoxytetrahydrofuran (5 eqv.), TfOH (3.5 eqv.), RT, 2h.
Determined by GCMS.
Isolated yields after flash chromatography.