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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Mol Aspects Med. 2008 Sep 6;30(1-2):86–98. doi: 10.1016/j.mam.2008.08.009

Fig. 1.

Fig. 1

Glutathione synthesis. The first step in glutathione (GSH) synthesis is carried out by glutamate cysteine ligase (GCL), which is composed of catalytic (GCLC) and modifier (GCLM) subunits. In this rate-limiting step, glutamate and cysteine are ligated to form γ-glutamylcysteine (γ-GC). The second step is carried out by glutathione synthetase (GS), which ligates glycine to γ-GC. Both steps are ATP dependent.