Table 3.
Association of alleles at rs5029939 with SLE sub-phenotypes compared to healthy controls.
| CG | GG | Attributable Risk | OR | ||||
|---|---|---|---|---|---|---|---|
|
|
|||||||
| Trait | Case:Cont | Case:Cont | CG GG | 95% CI | CG GG | 95% CI | P-value |
| SLE | 144:71 | 1198:1101 | 0.15 | 0.08–0.21 | 1.86 | 1.39–2.51 | 3.75E-05 |
| Anti-Ro/SSA | 22:25 | 173:347 | 0.14 | −0.01–0.27 | 1.77 | 0.97–3.22 | 0.065 |
| Anti-La/SSB | 9:25 | 61:348 | 0.16 | −0.02–0.31 | 2.05 | 0.91–4.62 | 0.082 |
| Nephritis | 49:71 | 330:1101 | 0.19 | 0.11–0.27 | 2.30 | 1.57–3.38 | 2.27E-05 |
| Malar Rash | 80:71 | 703:1101 | 0.14 | 0.06–0.21 | 1.77 | 1.26–2.46 | 9.0E-04 |
| Discoid Rash | 4:71 | 77:1101 | −0.04 | −0.22–0.14 | 0.81 | 0.29–2.27 | 0.68 |
| Photosensitivity | 89:71 | 748:1101 | 0.15 | 0.07–0.22 | 1.85 | 1.33–2.56 | 2.0E-04 |
| Arthritis | 112:71 | 961:1101 | 0.14 | 0.07–0.21 | 1.81 | 1.33–2.56 | 2.0E-04 |
| Oral Ulcers | 59:71 | 548:1101 | 0.13 | 0.04–0.21 | 1.46 | 0.90–2.36 | 0.12 |
| Serositis | 64:71 | 538:1101 | 0.15 | 0.06–0.23 | 1.85 | 1.30–2.63 | 7.0E-04 |
| Neurologic | 13:71 | 171:1101 | 0.04 | −0.10–0.17 | 1.18 | 0.64–2.18 | 0.60 |
| Hematologic | 88:71 | 661:1101 | 0.18 | 0.10–0.24 | 2.06 | 1.49–2.86 | 1.58E-05 |
| Immunologic | 97:71 | 809:1101 | 0.15 | 0.07–0.22 | 1.86 | 1.35–2.56 | 1.0E-0-4 |
| ANA | 148:14 | 1277:228 | 0.13 | 0.02–0.23 | 1.89 | 1.07–3.33 | 0.028 |
ANA = anti-nuclear antibodies
Cont = Control