Fig. 4.

Outline of adhesive signaling in migration. Integrin ligation induces the nucleation of different signaling elements. The major categories (kinases, non-catalytic adaptor proteins and actin-binding proteins) are shown. These categories can influence the recruitment and/or activation of other components of adhesions (represented by red arrows). Most migratory signaling converges on the Rho GTPases, which regulate actin polymerization and stability (via nucleators such as the Arp2/3 complex and formins, or actin-filament-severing proteins such as cofilin), actomyosin contractility (via MLC phosphorylation), and microtubules (not shown).