Table 1.
Findings in 17 Itgb8–/– adult mice
| Age at death (days) | Observations | Cause of death |
|---|---|---|
| 21 | Impaired mobility | D |
| 25 | Impaired mobility | D |
| 26 | Impaired mobility | D |
| 35 | Impaired mobility | D |
| 40 | Rectal prolapse, periorbital abscess | S |
| 56 | Weakness in hind limbs | S |
| 60 | Impaired mobility | D |
| 62 | Impaired mobility | D |
| 65 | Rectal prolapse | S |
| 65 | Weakness in hind limbs | S |
| 66 | Sparse hair | D |
| 72 | Weakness in hind limbs | S |
| 72 | Impaired mobility | D |
| 72 | Genital prolapse | S |
| 72 | Immobile | S |
| 86 | Weakness in hind limbs, pyometra | S |
| 92 | Impaired mobility | D |
| 74 | Weakness in hind limbs | S |
Itgb8–/– mice were observed until death or until sacrifice was required because of morbidity (which was most often due to poor mobility and inability to feed)
D, natural death; S; sacrificed