Table 2. Functional categories associated with diabetic cardiomyopathy.
| Term | Count | % | P Value |
| Biological Process | |||
| development | 77 | 15.78% | 0.0064 |
| response to stress | 46 | 9.43% | 8.55E-04 |
| defense response | 45 | 9.22% | 1.58E-05 |
| cell adhesion | 36 | 7.38% | 3.87E-07 |
| cell differentiation | 36 | 7.38% | 0.0081 |
| intracellular signaling cascade | 34 | 6.97% | 0.0182 |
| cell-cell signaling | 33 | 6.76% | 3.23E-04 |
| response to external stimulus | 30 | 6.15% | 1.14E-04 |
| response to wounding | 29 | 5.94% | 4.34E-06 |
| cell proliferation | 29 | 5.94% | 0.0047 |
| cell motility | 19 | 3.89% | 0.0067 |
| cell migration | 15 | 3.07% | 0.0053 |
| cell activation | 12 | 2.46% | 0.0074 |
| muscle contraction | 11 | 2.25% | 0.0045 |
| induction of apoptosis | 11 | 2.25% | 0.0202 |
| nucleotide metabolism | 11 | 2.25% | 0.0310 |
| ion homeostasis | 10 | 2.05% | 0.0445 |
| transmembrane receptor protein tyrosine kinase signaling pathway | 9 | 1.84% | 0.05 |
| Cellular Components | |||
| extracellular region | 88 | 18.03% | 4.42E-06 |
| plasma membrane | 70 | 14.34% | 0.0019 |
| intrinsic to plasma membrane | 43 | 8.81% | 0.0061 |
| integral to plasma membrane | 42 | 8.61% | 0.0082 |
| extracellular matrix | 13 | 2.66% | 0.0169 |
| sarcomere | 6 | 1.23% | 0.0127 |
| myofibril | 6 | 1.23% | 0.0190 |
| contractile fiber | 6 | 1.23% | 0.0347 |
| Molecular Function | |||
| protein binding | 129 | 26.43% | 0.0020 |
| ion binding | 60 | 12.30% | 0.0417 |
| calcium ion binding | 35 | 7.17% | 2.03E-06 |
| receptor binding | 26 | 5.33% | 0.0221 |
| electrochemical potential-driven transporter activity | 12 | 2.46% | 0.0100 |
| cytokine activity | 10 | 2.05% | 0.05 |
| lipid binding | 10 | 2.05% | 0.0430 |
| oxidoreductase activity, acting on CH-OH group of donors | 8 | 1.64% | 0.0329 |
| hormone activity | 8 | 1.64% | 0.0373 |
| phospholipid binding | 7 | 1.43% | 0.0354 |
| protein tyrosine phosphatase activity | 6 | 1.23% | 0.0485 |
| KEGG Pathway | |||
| RNO01430:CELL COMMUNICATION | 9 | 1.84% | 0.05 |
| RNO04512:ECM-RECEPTOR INTERACTION | 8 | 1.64% | 0.0183 |
| RNO04610:COMPLEMENT & COAGULATION CASCADES | 7 | 1.43% | 0.0165 |
| RNO00630:GLYOXYLATE AND DICARBOXYLATE METABOLISM | 3 | 0.61% | 0.0396 |
| SP_PIR_Keywords | |||
| glycoprotein | 75 | 15.37% | 1.33E-06 |
| transmembrane | 75 | 15.37% | 1.93E-05 |
| membrane | 75 | 15.37% | 4.11E-05 |
| signal | 69 | 14.14% | 1.21E-08 |
| receptor | 37 | 7.58% | 0.0203 |
| hydrolase | 31 | 6.35% | 0.02645 |
| calcium | 23 | 4.71% | 4.92E-04 |
| transducer | 17 | 3.48% | 0.0458 |
| cell adhesion | 16 | 3.28% | 6.13E-06 |
| g-protein coupled receptor | 16 | 3.28% | 0.0393 |
| phosphoprotein | 16 | 3.28% | 0.0457 |
| acetylation | 13 | 2.66% | 0.0183 |
| developmental protein | 13 | 2.66% | 0.0209 |
| egf-like domain | 9 | 1.84% | 0.0062 |
| cytokine | 7 | 1.43% | 0.0183 |
| inflammatory response | 6 | 1.23% | 0.0012 |
| hormone | 6 | 1.23% | 0.0380 |
| sulfation | 5 | 1.02% | 0.0021 |
| muscle protein | 5 | 1.02% | 0.0306 |
Categories ascribed to genes were determined from the Gene Ontology (GO) listings found in Genespring, DAVID and Ingenuity. Count represents the number of genes associated with a specific term. GO annotation may classify genes more than once in any given category.