Table 1.

Changes in Lipid Metabolism in HIV Infection

HIV-Infected Naïve Patients

↑ Triglyceride

↑ VLDL

↑ VLDL triglyceride production rates

↑Small, dense LDL

HIV Patients Treated with IP Based Regimen

↑ Triglyceride

↑Total Cholesterol

↑ VLDL, IDL, LDL-c, cholesterol ↓Postprandial delipidation

↑ Apo B-100          ↓VLDL to IDL/LDL transfer

↑ Apo E            ↓VLDL and LDL catabolic rates

↑ ApoC-III          ↓Hepatic lipase activity

↑ VLDL production       ↓Lipoprotein lipase activity

VLDL - very low-density lipoprotein (LDL), HDL – high density lipoprotein, IDL – intermediate-density lipoprotein, Apo – apolipoprotein.