Table 3.

Likelihood ratio in favor of causality for selected neutral variants

Gene	HGVS1	traditional2	protein	# fam3	LR per family4	LR-variant5
BRCA1	c.135-15_135-12del6	IVS4-15delCTTT	p.=	19	3.8592 (2+)	3.8592
BRCA1	c.2613G>A7	2732G>A	p.Pro871Pro	1	1.8533(2+)	1.8533
BRCA1	c.5152+20T>A7	IVS18+20T>A	p.=	1	3.6711(1+; 1+)	3.6711
BRCA2	c.125A>G8	353A>G	p.Y42C	2	0.9728(2+)	0.7405
					0.7612(1+; 4+)

^1–5 For clarification see Table 1.

These variants are regarded to be neutral towards cancer risk based on ⁶Vreeswijk et al. [15], ⁷Splice site prediction analysis and ⁸Goldgar et al. [3].

⁹ Pedigree is shown in Additional file 1; Figure S4.