Table 4.
Association of disc change classification status and putative risk factors in the Collaborative Initial Glaucoma Treatment Study (CIGTS) five-year optic disc study
| Putative Risk Factors | Disc Change Classification | P-value | Total | ||
|---|---|---|---|---|---|
| Reversal of Cupping N=23 | No Change N=303 | Glaucomatous Progression N=22 | |||
| Mean (SD) Sphere (diopters) | −1.9 (2.7) | −1.2 (2.7) | −1.7 (2.5) | 0.32a | −1.3 (2.7) |
| N (%)Sphere ≤ −6 | 1 (4%) | 27 (9%) | 3 (14%) | 0.58c | 31 (9%) |
| Mean (SD) Follow-up IOP | 10.2 (3.8) | 16.7 (4.5) | 17.4 (3.1) | <0.001a | 16.4 (4.7) |
| N (%) Follow-up IOP ≤5 mmHg | 1 (5%) | 2 (1%) | 0 | 0.34c | 3 (1%) |
| Mean (SD) Baseline minus Follow-up IOP | 17.5 (5.5) | 10.8 (6.2) | 11.5 (6.7) | <0.001a | 11.3 (6.3) |
| Mean (SD) Baseline Acuity (ETDRS letters) | 85.4 (4.8) | 86.2 (5.6) | 86.7 (5.6) | 0.72a | 86.2 (5.5) |
| Mean (SD) Follow-up Acuity (ETDRS letters) | 78.9 (15.1) | 84.1 (9.2) | 83.9 (11.0) | 0.054a | 83.8 (9.8) |
| Mean (SD) Baseline minus Follow-up Acuity (ETDRS letters) | −6.5 (15.0) | −2.1 (8.8) | −2.8 (10.3) | 0.098a | −2.4 (9.5) |
| Mean (SD) Horizontal Cup/Disc Ratio | 0.63 (0.18) | 0.61 (0.22) | 0.60 (0.19) | 0.86a | 0.61 (0.22) |
| Mean (SD) Vertical Cup/Disc Ratio | 0.68 (0.15) | 0.64 (0.22) | 0.66 (0.18) | 0.66a | 0.64 (0.21) |
| Mean (SD) Age at Randomization | 55.6 (11.8) | 57.6 (10.6) | 57.0 (11.1) | 0.66a | 57.4 (10.7) |
| N (%) African American Ancestry | 5 (22%) | 118 (39%) | 9 (41%) | 0.25b | 132 (38%) |
a
One-way analysis of variance
b
Chi-square test
c
Exact permutation chi-square test