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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Arthritis Rheum. 2008 Aug;58(8):2296–2306. doi: 10.1002/art.23610

Figure 2.

Figure 2

Effect of the matrix metalloproteinase inhibitor GM6001 on the invasive properties of fibroblast-like synoviocytes (FLS) derived from DA rats and FLS from DA.F344(Cia5d) rats. FLS from DA and DA.F344(Cia5d) were plated on Matrigel-coated invasion chambers, with or without 25 µM GM6001, for 24 hours. The absorbance of invading cells from DA (n = 12) was significantly reduced in the presence of GM6001. The absorbance of invading cells from DA.F344(Cia5d) without GM6001 (n = 7) was significantly lower than that of cells from DA without GM6001 and was similar to that of cells from DA treated with GM6001. Bars show the mean and SD. * = P = 0.018; # = P = 0.004 versus FLS from DA without GM6001, by t-test.