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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Arthritis Rheum. 2008 Aug;58(8):2296–2306. doi: 10.1002/art.23610

Figure 5.

Figure 5

Soluble and plasma membrane type 1 matrix metalloproteinase (MT1-MMP) in fibroblast-like synoviocytes (FLS). A, DA FLS cultured for 24 hours had reduced MT1-MMP activity in plasma membranes, compared with DA.F344(Cia5d) FLS. Values are the median and 25th and 75th percentiles. P = 0.052, by Mann-Whitney test. B, Western blotting showed increased levels of soluble MT1-MMP (sMT1-MMP) in supernatants of DA rat FLS (n = 3) compared with DA.F344(Cia5d) rat FLS (n = 3) cultured on Matrigel-coated Petri dishes (5 µg of protein loaded per lane). The data for sMT1-MMP were replicated in 3 additional FLS cell culture supernatants per strain.