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. Author manuscript; available in PMC: 2010 Apr 21.
Published in final edited form as: Biochemistry. 2009 Apr 21;48(15):3378–3386. doi: 10.1021/bi900057g

Figure 1. Catalytic Loop of Selected Kinases.

Figure 1

A) Amino acid sequence of the catalytic loop region for Src (residues 384–391), Abl (residues 361–368), Csk, insulin receptor tyrosine kinase (IRK), and epidermal growth factor receptor kinase (EGFR). The D+2 Arg and D+4 Arg that are examined here are in bold. B) Schematic of the interaction of the catalytic loop residues corresponding to Asp363 and Arg367 in Csk with the substrate tyrosine, as observed in the crystal structure of inhibited IRK.