Skip to main content
. Author manuscript; available in PMC: 2010 Apr 21.
Published in final edited form as: Biochemistry. 2009 Apr 21;48(15):3378–3386. doi: 10.1021/bi900057g

Figure 2. Extension of N-terminus of One R388A SrcKD Molecule into the Active Site of Another.

Figure 2

The relative orientation of three kinase molecules are shown as observed in the crystal. The N-terminal kinase domain-SH2 domain linker extends for 27 Å inserting the side-chain of His249 (green) deep into the active site of another molecule (orange), complementing the cavity created by the R388A mutation (pop-out).