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. 2009 Aug;15(8):1433–1442. doi: 10.1261/rna.1703809

FIGURE 1.

FIGURE 1.

Domain organization of GW182 proteins. (Hs) Homo sapiens; (Dm) Drosophila melanogaster. (N-GW, M-GW, C-GW) N-terminal, middle, and C-terminal GW-repeat-containing regions, respectively (the number of GW-repeats for each region is indicated in brackets). The white sectors within the N-terminal regions do not contain GW-repeats. UBA (gray box): ubiquitin associated-like domain; Q-rich (blue box): region rich in glutamine; RRM (red box): RNA recognition motif. Fuchsia boxes I and II: two conserved motifs within the N-terminal GW repeats. Violet box: Ago-hook motif. Orange box: conserved motif III (DUF). Numbers underneath the protein schematic represent amino acid positions at fragment boundaries for each protein. The AGO-binding and silencing domains are indicated. C. elegans (Ce) AIN-1 and AIN-2 proteins are included for comparison.