Table 2. Sequence alterations detected and investigated in PACG and control groups.
| Sequence change |
Allele distribution (%) |
Allele association p-value | Odds ratio (95%CI) |
Genotype distribution (%) |
Genotype association p-value | ||||
|---|---|---|---|---|---|---|---|---|---|
| PACG n=211 | Control n=205 | PACG n=211 | Control n=205 | ||||||
|
rs17576 |
A |
108(25.6) |
87(21.2) |
0.126 |
1.28
(0.95-1.76) |
AA |
16 (7.6) |
6 (2.9) |
0.102 |
| c.836A>G; p.279Q>R |
G |
314(74.4) |
323(78.8) |
AG |
76 (36.0) |
75 (36.6) |
|||
| GG |
119 (56.4) |
124 (60.5) |
|||||||
|
rs2250889 |
G |
116(27.5) |
73(17.8) |
0.001 |
1.75
(1.26-2.44) |
GG |
19 (9.0) |
6 (2.9) |
0.004 |
| c.1722G>C; p.574R>P |
C |
306(72.5) |
337(82.2) |
GC |
78 (37.0) |
61 (29.8) |
|||
| CC | 114 (54.0) | 138 (67.3) | |||||||
Listed are allele and genotype frequencies of SNP rs17576 and rs2250889 in MMP9 among PACG and control groups from the south of Chinese population. The frequencies of genotypes distributions in PACG and control subjects conformed to the Hardy-Weinberg equilibrium. Data are given as numbers (percentage). The p-value was calculated using the χ2 test (After Boferrni correction, a p <0.025 was considered to be significant). PACG indicates primary angle-closure glaucoma.