Figure 3.

Second ranking gene/protein networks determined by IPA analysis in Caucasian maternal (net work score 32) and fetal (net work score 29). Panel A, maternal networks; panel B, fetal networks. Solid lines show direct interaction (binding/physical contact); dashed line, indirect interaction supported by the literature but possibly involving one or more intermediate molecules that have not been investigated definitively. Molecular interactions involving only binding are connected with a solid line (no arrowhead) since directionality cannot be inferred. Focus genes: pink color, met criteria for case-control comparison for genotype at p ≤ 0.05; red, met criteria for case-control comparison for genotype at p ≤ 0.001; grey, indicating one or more SNP was analyzed in our data set but case-control comparison did not meet p ≤ 0.05; no color – additional interconnected genes generated algorithmically by IPA, i.e., proteins, or complexes, including new potential biomarkers. * indicates that there was more than one SNP probe for this gene tested and the most significant was placed into the analysis.