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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Genes Brain Behav. 2009 Feb 19;8(5):493–499. doi: 10.1111/j.1601-183X.2009.00485.x

Figure 2. Local knockdown of PKCε in the amygdala reduces ethanol intake under limited gaccess conditions.

Figure 2

Over 4 consecutive weeks of daily ethanol consumption under conditions of daily limited access, mice treated with control shRNA (n = 9) increased their ethanol intake (A) and ethanol preference (B), whereas mice treated with the 1845 PKCε shRNA (n = 9) did not. (C) Total fluid intake increased over 4 weeks similarly in both treatment groups. Control and PKCε shRNA treated mice consumed equal amounts of 20% sucrose (D) and 0.03 mM quinine (E) in 2-h sessions. * P < 0.05 compared with 1845 PKCε shRNA-treated mice by post-hoc Bonferroni test for intake in week 3 (t16 = 4.2, P < 0.001) and week 4 (t16 = 3.5, P < 0.01) and for preference in week 3 (t16 = 3.1, P < 0.01) and week 4 (t16 = 2.6, P < 0.05).