Table 1.
Properties of nerve-repair grafted and control medial gastrocnemius muscle with or without synergistic muscles intact in 6-mo-old male Fischer 344 rats
| Experimental Group | P Value | ||||||
|---|---|---|---|---|---|---|---|
| Sham control |
Nerve-repair grafted |
Synergist-ablated control |
Synergist-ablated nerve-repair grafted |
Effect of grafting |
Effect of ablation |
Effect of grafting × ablation |
|
| Muscle mass, g | 716 ± 14 (10) |
720 ± 23 (7) |
1,141 ± 42c (9) |
872 ± 24b,d,e (10) |
< 0.0001 | < 0.0001 | < 0.0001 |
| CSAf, mm2 | 55 ± 1 (10) |
56 ± 2 (7) |
84± 3c (9) |
65 ± 2b,d,e (10) |
< 0.0001 | < 0.0001 | < 0.0001 |
| Maximum tetanic tension, N | 1,367 ± 23 (10) |
1,060 ±52a(7) | 1,776 ± 45c (8) |
1,335 ± 23b,d (10) |
< 0.0001 | < 0.0001 | 0.057 |
| Specific force, N/cm2 | 25 ± 0.2 (10) |
19 ± 0.7a (7) |
21 ± 0.8c (8) |
21 ± 0.8e (10) |
< 0.0001 | 0.073 | < 0.0001 |
| Optimal velocity, Lf/s | 1.67 ±0.06 (10) |
1.75 ± 0.09 (6) |
1.44 ± 0.6c (9) |
1.3 ± 0.05d,e (10) |
NS | < 0.0001 | 0.077 |
| Normalized power, W/Kg | 182 ± 3 (10) |
111± 7a (6) |
107 ± 4c (9) |
88 ± 4b,d,e (10) |
< 0.0001 | < 0.0001 | < 0.0001 |
| Maximum normalized sustained power, W/kg |
4.8 ± 0.1 (9) |
3.7± 0.3a (10) |
4.5 ± 0.2 (10) |
5.1 ± 0.2b,d (10) |
NS | 0.021 | 0.0002 |
Values are means ± SE; nos. in parentheses is no. of rats for each group. CSAf, functional muscle fiber cross-sectional area; NS, not significant.
Nerve-repair grafted is significantly different from sham control group, P ≤ 0.05.
Synergist-ablated nerve-repair grafted is significantly different from synergist-ablated control group, P ≤ 0.05.
Synergist-ablated control is significantly different from sham control group, P ≤ 0.05.
Synergist-ablated nerve-repair grafted is significantly different from nerve-repair grafted group, P ≤ 0.05.
Synergist-ablated nerve-repair grafted is significantly different from sham control group, P ≤ 0.05.