Table 2.

Meconium buprenorphine and metabolite concentrations

	subject
	A	B	C	D (Baby 1)	D (Baby 2)	E	F	G	H	I	Mean ± sea	Median	Range
Free BUP ng/g	101.6	47.4	101.0	59.3	59.6	240.5	NDb	23.9	40.4	165.4	93.2 ± 22.1	59.6	23.9–240.5
Total BUP ng/g	123.8	95.9	131.3	96	169.6	296.8	24.3	32.1	91.6	245.9	130.7 ± 27.4	109.9	24.3–296.8
% Free BUP	82.0	49.4	76.9	61.7	35.1	81.0	—c	74.4	44.1	67.3	63.6 ± 5.7	67.3	35.1–82.0
Free NBUP ng/g	712.6	497.5	398.2	468.4	373.4	1228.6	331.1	730.6	505.4	858.4	610.4 ± 87.7	501.5	331.1–1228.5
Total NBUP ng/g	719.3	689.2	447.5	548.1	607.6	1880.2	323.9	629.9	955.6	737.1	753.8 ± 136.3	659.5	323.9–1880.2
% Free NBUP	99.1	72.2	89.0	85.5	61.5	65.3	102.2	116.0	52.9	116.5	86.0 ± 7.1	87.2	52.9–116.5
Free BUP/Free NBUP	0.14	0.10	0.25	0.13	0.16	0.20	—	0.03	0.08	0.19	0.14 ± 0.02	0.14	0.03–0.25
Total BUP/Total NBUP	0.17	0.14	0.29	0.18	0.28	0.16	0.08	0.05	0.10	0.33	0.18 ± 0.03	0.17	0.05–0.33

BUP, buprenorphine; NBUP, norbuprenorphine.

^aMean ± SEM of positive specimens.

^bNot detected.

^cCannot be calculated.