Fig. 7.

Modulation of promotion-driven excess relative cancer risk (ERR) over time after exposure: a low doses (either acute or fractionated produce similar results, since cell inactivation is negligible), b high fractionated doses (fractions are given once daily, with gaps on weekends). It is seen that, contrary to a proportional hazards assumption, not only the amplitude but also the shape of the dose–response curve is altered by long-term processes. The parameters were the same as in previous figures