Table 1.
Summary of model parameters
| Parameter | Units | Interpretation |
|---|---|---|
| a | time−2 | Spontaneous stem cell initiation and transformation |
| b | time−1 | Pre-malignant niche replication |
| c | time−2 | Age-dependent pre-malignant cell senescence |
| δ | time−1 | Homeostatic regulation of pre-malignant cell number per niche |
| Z | cells/niche | Carrying capacity for pre-malignant cells per niche |
| X | time/dose | Radiation-induced initiation |
| Y | dose−1 | Radiation-induced promotion |
| α, β | dose−1, dose−2 | Stem cell inactivation by radiation |
| λ | time−1 | Maximum net stem cell proliferation (repopulation) rate |
| L | time | Lag period between the first malignant cell and cancer |