Figure 2. FBXW7 alterations are common in human T-ALL and conserved in the murine TKO tumours.

a, log₂ ratio of array-CGH plots showing conserved deletion of FBXW7 in both mouse TKO and human T-ALL cell lines; FBXW7 is indicated in green. The y axis shows log₂ of copy number ratio (normal, log₂ = 0); amplifications are above and deletions are below this axis; x axis, chromosome position, in Mbp. b, Relative expression level (by real-time quantitative PCR) of mouse Fbxw7 mRNA in murine TKO tumours, with expression in normal thymus (thymus A) set at 1; an independent normal thymus sample (thymus B) was run for comparison. c, Location of FBXW7 mutations in a panel of human T-ALL patients and cell lines. Each marker represents an individual cell line/patient.