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. Author manuscript; available in PMC: 2009 Jul 24.
Published in final edited form as: Nature. 2007 May 21;447(7147):966–971. doi: 10.1038/nature05886

Figure 3. Conservation of PTEN genetic alterations in human and mouse T-ALLs.

Figure 3

a, Array-CGH plots showing conserved deletion of PTEN in both mouse TKO and human T-ALL cell lines; PTEN indicated in green. The y axis shows, log2 ratio of copy number (normal, log2 = 0); amplifications are above and deletions are below the red axis. b, Western blotting for PTEN, phospho-Akt, Akt and tubulin (loading control) in a panel of murine TKO and human T-ALL cell lines. BE13 and PEER are synonymous lines. Samples in red harbour confirmed sequence mutations; samples in blue harbour aCGH-detected deletions. c, CNAs affecting other members of the Pten-Akt axis are shown as log2 ratio plots for murine TKO tumours. The location of each gene (Akt1/Tsc1) is shown in green.