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. 2009 Jun 8;206(6):1339–1350. doi: 10.1084/jem.20082316

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© 2009 Fukui et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 4. — Differential regulation of ligand-induced TLR7/9 trafficking by Unc93B1 (A) WT Unc93B1-GFP and D34A Unc93B1-cherry were coexpressed in Ba/F3 cells, and live cells were imaged. The merged and differential interference contrast (DIC) images are shown. (B) Ba/F3 cells expressing cathepsin B+L and TLR9-GFP were further transfected with WT (left) or D34A (right) Unc93B1. These cells were left unstimulated (top) or stimulated with 100nM CpG-B for 60 min (bottom). Cells were stained with a lysosome marker. Green and red images were merged (left), or merged images were further imposed on DIC images (right). (C) TLR9-GFP in B was replaced with TLR7-GFP and 5 µg/ml imiquimod was used as the stimulant. These experiments were repeated four times and represented images are shown. Bars, 5 µm.