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. 2009 Jun 8;206(6):1365–1378. doi: 10.1084/jem.20090127

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© 2009 Doisne et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 8. — Schematic model summarizing the effects of the three branches of TGF-β signaling on iNKT cell differentiation. The Tif-1γ–dependent branch prevents the apoptosis and allows lineage expansion. The Tif-1γ/Smad4-independent branch prevents maturation, and thus allows lineage expansion. The Smad4-dependent branch allows maturation.