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. 2009 Jun 8;206(6):1291–1301. doi: 10.1084/jem.20082767

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© 2009 Minegishi et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — HIES T cells produce greatly reduced amounts of Th17 cytokines and normal amounts of classical proinflammatory cytokines upon activation. PBMCs from HIES patients (Pt.) and control subjects (Cont.; n = 8 each, indicated by dots) were stimulated (+) or not (−) with anti-CD3 and anti-CD28 for 72 h, and the concentration of the indicated cytokines in their culture supernatants was determined by ELISA. The results shown are representative of three independent experiments. **, P < 0.01.