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. 2009 Jun 8;206(6):1303–1316. doi: 10.1084/jem.20090299

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© 2009 Pöllinger et al.

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Figure 2. — Spontaneous RR-EAE in TCR transgenic SJL/J mice. (A) Male and female single-transgenic TCR¹⁶⁴⁰ compared with double-transgenic TCR¹⁶⁴⁰ × IgH^MOG mice. Shown is the spontaneous incidence of first signs of ataxia or classical EAE-like symptoms in TCR¹⁶⁴⁰ (left) and double-transgenic TCR¹⁶⁴⁰ × IgH^MOG (right) mice. TCR¹⁶⁴⁰ females (f), n = 12; males (m), n = 27; TCR¹⁶⁴⁰ × IgH^MOG females, n = 20; males, n = 26; TCR¹⁶⁴⁰ × Mog^−/− mice, n = 6. Disease kinetic of genders in TCR¹⁶⁴⁰ mice was not statistically significant (P = 0.304) but differed significantly between sexes of TCR¹⁶⁴⁰ × IgH^MOG mice (P = 0.0004). (B) Histological analysis of cerebellum and spinal cord from a sick TCR¹⁶⁴⁰ mouse (RR mouse) with ataxia and classical paralysis. Cerebellum (I–IV) and spinal cord (V–VIII) showed severe infiltration, demyelination, and axonal damage as visualized by immunohistochemistry using anti-CD3 (I and V) and anti–Mac3 antibodies (II and VI), Luxol fast blue staining (III and VII), and Bielschowsky silver impregnation (IV and VIII). I, II, V, and VI were counterstained by hematoxylin and eosin (H&E). Magnification: ×17 (cerebellum) and ×30 (spinal cord). Bars, 1 mm. Data are representative of at least two independent experiments consisting of more than three mice per group.