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. 2009 Jun 8;206(6):1303–1316. doi: 10.1084/jem.20090299

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© 2009 Pöllinger et al.

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Figure 4. — Ig deposition and B cell infiltrates in spinal cord of sick TCR¹⁶⁴⁰ × IgH^MOG and TCR¹⁶⁴⁰ mice. (A–D) Histological analysis of spinal cord using anti-Ig antibodies shows deposition of Ig in sick TCR¹⁶⁴⁰ × IgH^MOG (A and B) and TCR¹⁶⁴⁰ (C and D) mice (B and D show magnifications of marked areas in A and C, respectively). (E) Anti-B220 staining revealed some B cells among cellular infiltrates in sick TCR¹⁶⁴⁰ mice. (F) Deposition of complement C9neo within CNS lesions of TCR¹⁶⁴⁰ mice. Mononuclear cells were stained with H&E. Magnifications: A and C, ×50; B, ×425; D and E, ×200; F, ×450. Bars: (A and C) 1 mm; (B and D–F) 100 µm. Data are representative of at least two independent experiments consisting of more than three mice per group.