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. 2009 Apr 13;206(4):743–750. doi: 10.1084/jem.20081787

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© 2009 Toulon et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 5. — IGF-1 and IL-2 production by T cells in normal epidermis and chronic nonhealing wounds. (A) IGF-1 production by αβ⁺ and Vδ1⁺ T cells is significantly higher after stimulation in normal epidermis (n = 17) compared with chronic wounds (n = 8). Plots represent IGF-1 production by individual donors with or without stimulation with PMA and ionomycin. (B) The percentage of αβ⁺ (left) and Vδ1⁺ (right) T cells producing IL-2 before and after stimulation with PMA and ionomycin in normal epidermis (n = 5) and nonhealing chronic wounds (n = 3). Although no difference in IL-2 production by αβ⁺ and Vδ1⁺ T cells in normal epidermis compared with chronic wounds was seen before stimulation, the percentage of αβ⁺ and Vδ1⁺ cells producing IL-2 after stimulation is significantly lower in chronic wounds. Data were compared using a one-tailed unpaired Student's t test. Horizontal bars represent means of the values from the different patients.