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In vivo infection by MMTV. DCs in the gut get infected by MMTV, then traffic to the lymph node where they present Sag to cognate T cells. The T cells get activated, secrete cytokines and provide B and DC cell help, thereby creating a reservoir of infection-competent lymphocytes. Infected B cells then further amplify infection by presenting Sag to T cells. The infected lymphoid cells traffic to the mammary gland, where they transmit virus to mammary epithelial cells (MGE).
