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. Author manuscript; available in PMC: 2009 Jul 24.
Published in final edited form as: J Am Chem Soc. 2006 May 31;128(21):6804–6805. doi: 10.1021/ja061731n

Table 1.

Salt effect

graphic file with name nihms-64035-t0004.jpg
entrya catalyst salt time eeb favored
enantiomerc
1 L-proline -- 24 h 49 S
2 L-proline LiCl 24 h <5 --
3 C-HOAc -- 2 h 67 R
4 C-HOAc LiCl 2 h 80 R
a

Yield of all reactions > 80% as measured by 1H NMR of the crude reaction mixture before reduction; the reduction is quantitative.

b

Determined by chiral phase HPLC.

c

See supporting information for stereochemistry determination.