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. 2009 May 12;37(13):4205–4217. doi: 10.1093/nar/gkp341

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© 2009 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Domain structure and alignment of Cwc2. (A) Depiction of the protein motifs found in Cwc2. The location of the zinc finger and RRM are shown. The region of Cwc2 (amino acids 228–339) found to interact with Prp19 by two-hybrid and pull-down analysis is also shown (9). (B) Comparison of consensus RNP1 and RNP2 sequences with Cwc2 RNP1 and RNP2 sequences (X is for any amino acid). The aromatic residues, which are important for RNA binding, are highlighted. (C) The amino acid sequence of Cwc2 from S. cerevisiae (Sc, NCBI-GI: 6319992) was aligned with orthologs from K. lactis (Kl, NCBI-GI: 50305857), A. fumigatus (Af, NCBI-GI: 70998470), S. pombe (Sp, NCBI-GI: 19114249) and Homo sapiens (Hs, NCBI-GI: 8922328). Orthologs were identified using KEGG and the alignment was made with ClustalW and Jalview.