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. 2009 May 13;37(13):4264–4274. doi: 10.1093/nar/gkp390

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© 2009 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — ROS1 activity on hemimethylated and bimethylated DNA. (A) Structure and length of the DNA substrates and products. X indicates target base. (B) Purified ROS1 (22.5 nM) was incubated with 20 nM duplex DNA labelled on both strands that contained a single hemimethylated or a bimethylated CG site. Reactions were stopped at the indicated times and products were separated in a 12% denaturing polyacrylamide gel. The number of incisions on the upper (filled symbols) and/or lower (open symbols) strand on the hemimethylated (circles) and bimethylated (triangle) DNA substrate was quantified by fluorescence scanning.