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. 2009 May 21;37(13):4385–4392. doi: 10.1093/nar/gkp391

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© Published by Oxford University Press 2009

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Representative metaphases seen in FX lymphoblasts after treatment with 1 µM FdU and/or 100 nM UCN-01. (A) X chromosome showing breakage of both sister chromatids. (B) FISH showing X chromosome in which one chromatid shows what appears to be a partial duplication of part of the FRAXA region. (C) X chromosome in which one chromatid has lost the FRAXA region and the other has two copies of that region. (D) X chromosome in which the end of the long arm of the sister chromatids are linked by three copies of the FRAXA region.