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. 2009 May 20;37(13):4331–4340. doi: 10.1093/nar/gkp393

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© 2009 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — The methylation profile of CpG sites sequenced. (A) CpG methylation near transcription start sites (TSSs). The X-axis represents the distance of CpG sites sequenced to the TSSs. The Y-axis represents the average methylation level. The average methylation levels were calculated for CpG sites adjacent to TSSs in 100-bp increments. (B) Spatial methylation correlation surrounding unmethylated CpG sites. The X-axis represents the distance to the nearest unmethylated CpG site. The Y-axis represents the average methylation level. The average methylation level of CpG dinucleotides were determined and plotted against the spatial distance, in 10-bp increments, to the nearest unmethylated CpG site.