Figure 6.

Adoptive transfer of lung T cells from sensitized and challenged CD4−/− mice reconstitutes AHR. Donor CD4+/+ or CD4−/− mice were sensitized and challenged or challenged alone. Lung T cells were isolated and injected intravenously into naive CD4+/+ or CD4−/− recipients who then received 6 d of airway allergen challenge (n = 8 for each group). *P < 0.05 sensitized and challenged versus challenged alone donor CD4−/− mice into recipient CD4−/− mice; *P < 0.05 for all other combinations of sensitized and donor mice versus challenged alone (data not shown).