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. 2005 May 12;33(2):145–152. doi: 10.1165/rcmb.2004-0330OC

Figure 2.

Figure 2.

Infusion of BMDMSC reduces lung damage induce by bleomycin. Morphometric analysis of histologic sections of total left lung was done to determine the percentage of the lung that was affected. Pictures (magnification: ×2) were analyzed using AxioVision 4.2 software (Carl Zeiss, Thornwood, NY). The graphic represents the average from 5–9 histologic lung sections. Bleomycin caused substantial injury and BMDMSC infusion reduced bleomycin-induced injury (*P < 0.05, bleomycin-BMDMSC versus bleomycin, versus busulfan-bleomycin, and versus busulfan-bleomycin-BMDMSC). In myelosuppressed animals, this measure of injury was on average worse than in nonmyelosuppressed animals and on average less severe when animals received BMDMSC. Since only the lungs of the one-third of the myelosuppressed animals that received BMDMSC survived to 14 d were analyzed, the histologic measurements likely underestimate the degree of injury in the entire group.