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. 2005 May 12;33(2):145–152. doi: 10.1165/rcmb.2004-0330OC

Figure 5.

Figure 5.

BMDMSC infusion attenuates bleomycin-induced increases in lung expression of immune-related cytokines and increases circulating concentrations of G-CSF and GM-CSF. (a) Serum concentrations of G-CSF and GM-CSF in control animals (n = 4) and 14 d after bleomycin with (n = 4) or without (n = 5) BMDMSC transfer. BMDMSC transfer resulted in significantly elevated serum concentrations of both factors. The differences were significant (P < 0.05) after one-way ANOVA and repeated-measures ANOVA between animals treated with BMDMSC and the other two groups (**). (b) Expression of cytokines in lung tissue determined by real-time PCR in control mice, (n = 3) and mice given bleomycin with (n = 3) or without (n = 3) BMDMSC transfer 14 d after bleomycin. Bleomycin treatment caused prolonged increased expression of these immune-related cytokines and transfer BMDMSC tended to suppress this response.