TABLE 1.
Circulating leukocytes in TIMP-1–deficient and wild-type mice (mean ± sem).
| Genotype | Condition | Total Number of Leukocytes (× 10−3/μl) |
Neutrophils (%) | Lymphocytes (%) | Monocytes (%) | Eosinophils (%) |
|---|---|---|---|---|---|---|
| TIMP-1 WT (n = 6) | Control | 7.6 ± 0.47 | 16.0 ± 3.4 | 78.0 ± 2.7 | 0 | 5.0 ± 1.1 |
| TIMP-1 KO (n = 8) | Control | 6.8 ± 0.36 | 16.0 ± 1.5 | 81.0 ± 1.6 | 0 | 3.0 ± 0.7 |
| P value | 0.2 | 0.83 | 0.38 | NS | 0.10 | |
| TIMP-1 WT (n = 5) | Day 7 Bleomycin | 5.4 ± 0.76 | 50.0 ± 8.5 | 47.6 ± 8.5 | 1 ± 0.8 | 0.8 ± 0.5 |
| TIMP-1 KO (n = 6) | Day 7 Bleomycin | 5.2 ± 0.78 | 52.3 ± 7.9 | 44.7 ± 6.8 | 1.8 ± 0.9 | 1.2 ± 0.7 |
| P value | 0.82 | 0.87 | 0.79 | 0.50 | 0.66 |
Definition of abbreviations: KO, knockout; TIMP-1, tissue inhibitor of metalloproteinase-1; WT, wild type.